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Pain & Inflammation Signals

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How the body signals inflammation — and what the research says about reading it.

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Inside the ProleevaMax Studies: What They Found, and What They Didn't

Two small human studies of ProleevaMax exist. Neither was controlled. Here is exactly what each one measured, what it found, and where the reports disagree.

September 18, 2026·Fabio Lanzieri

More in Pain & Inflammation Signals

Pain & Inflammation Signals
Can You Take Boswellia With Ibuprofen?
Can you take boswellia and ibuprofen together? What to know about combining them, who should check with a doctor first, and the question people mean.
September 9, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Menopause, Estrogen and Inflammation: What the Evidence Shows
Why menopause symptoms cluster rather than arrive separately: estrogen is anti-inflammatory, and what happens to inflammatory signalling when it falls.
September 7, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Oxidative Stress and Inflammation: How They Feed Each Other
Oxidative stress and inflammation feed each other in a self-driving loop. Here is the plain-language science on free radicals, antioxidants, and how to break in.
August 27, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Is Inflammation Good or Bad? Acute vs Chronic, Explained
Is inflammation good or bad? It is both. Acute inflammation protects and heals. Chronic inflammation harms. Here is how to tell the difference.
August 26, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Acute vs Chronic Inflammation: The Difference That Matters
Acute vs chronic inflammation: one heals you, the other wears you down. Learn the timelines, mechanisms, and why chronic matters most.
August 25, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Does Stress Cause Inflammation? The Cortisol Link
Does stress cause inflammation? Yes. Learn how the cortisol and HPA axis connection drives chronic inflammation, and the practical levers that help.
August 6, 2026·Maria Lanzieri
Pain & Inflammation Signals
Do Eggs Cause Inflammation? The Honest Answer
Do eggs cause inflammation? Clinical trials say no for most people, but individual response varies. Here is what the evidence shows for women 40-65.
August 3, 2026·Fabio Lanzieri
Pain & Inflammation Signals
What Causes Inflammation in the Body? The Root Causes Explained
What causes inflammation in the body? Diet, stress, sleep, visceral fat, smoking, infection, and aging all play a role. Here is the science.
July 21, 2026·Fabio Lanzieri
Pain & Inflammation Signals
How to Lower CRP Naturally: Evidence-Based Steps That Work
Learn how to lower CRP naturally with diet, exercise, sleep, and habit changes that research links to a healthier inflammatory response.
July 17, 2026·Fabio Lanzieri
Pain & Inflammation Signals
AG1 Alternatives: Options Worth Comparing (and How to Choose)
Comparing AG1 alternatives? See how greens powders, multivitamins, and targeted inflammation support differ on goal, cost per day, and design.
July 13, 2026·Fabio Lanzieri
Pain & Inflammation Signals
How to Test for Chronic Inflammation: What hs-CRP, ESR, and Homocysteine Actually Tell You
A pharma-led guide to testing for chronic inflammation: what hs-CRP, ESR, and homocysteine measure, how to read the ranges, the chronic-vs-acute distinction, and what the evidence says to do if levels are elevated.
July 10, 2026·Fabio Lanzieri
Pain & Inflammation Signals
The Inflammation-Anxiety Loop: What the Cytokine Research Actually Shows
How chronic inflammatory cytokines like IL-6 and TNF-alpha interact with the brain to heighten anxiety, what the cohort research shows, and where GABA, 5-HTP, and resveratrol genuinely fit.
July 1, 2026·Maria Lanzieri
Pain & Inflammation Signals
Perimenopause Hip Pain: The Connective Tissue and Inflammation Mechanism Behind It
Why new hip pain in perimenopause is often driven by estrogen loss and soft-tissue inflammation, not worn cartilage. The trochanteric-pain mechanism, the boswellia and curcumin evidence, and honest limits — with real citations.
June 26, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Why Does My Whole Body Ache? When It's Inflammation — and When to See a Doctor
Why does your whole body ache for no clear reason? When all-over body aches are an inflammation signal, when they're something else, and what actually helps.
June 24, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Why Do My Joints Hurt? The Inflammation Behind That Everyday Ache
Why do your joints hurt when nothing's wrong on the X-ray? The inflammatory signal behind everyday joint aches and stiffness — and what genuinely helps.
June 24, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Is Turmeric a Blood Thinner? What to Know Before You Combine It With Medication
Is turmeric a blood thinner? It has mild antiplatelet activity that can add to warfarin, aspirin, and other anticoagulants. Here's the doctor-first guidance.
June 24, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Can You Take Turmeric and Ibuprofen Together?
Can you take turmeric and ibuprofen together? For most healthy adults the occasional combination is low-risk — here's when it isn't, from someone who spent 40 years in pharma.
June 23, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Best Supplements for Menopause Joint Pain: What the Research Actually Supports
The best supplements for menopause joint pain, graded by real trial evidence — boswellia, curcumin, omega-3, collagen, and the honest gaps.
June 23, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Menopause as a Pro-Inflammatory Transition: What the Immunology Research Shows
Estrogen restrains the master inflammatory switch NF-κB. As estrogen declines through menopause, NF-κB activity rises and inflammatory signaling turns up body-wide — which is why joint pain, brain fog, weight gain, and mood changes cluster together. The mechanism, the markers, and honest guidance, with real citations.
June 15, 2026·Fabio Lanzieri
Pain & Inflammation Signals
The Joint Stiffness Playbook: A Complete Natural Management Strategy
A complete, evidence-based strategy for managing joint stiffness naturally — from morning routines and movement plans to nutrition, sleep positioning, and when to see a doctor.
June 2, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Perimenopause Weight Gain and Inflammation: The Visceral Fat Mechanism Nobody Explains
Maria Lanzieri on perimenopause belly weight as a signaling problem, not a willpower one: how falling estrogen drives visceral fat and NF-kappaB inflammation, and what genuinely helps.
May 28, 2026·Maria Lanzieri
Pain & Inflammation Signals
5-HTP and Chronic Pain — What the Fibromyalgia Research Actually Shows
Two Italian trials — Caruso 1990 (double-blind, placebo-controlled, n=50) and Sarzi Puttini 1992 (90-day open-label, n=200) — tested 5-HTP in fibromyalgia patients. Here's what the research actually found, the design limitations, and why serotonin's role in descending pain modulation is more important than its mood association.
May 27, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Inflammaging — The Slow-Burning Process That Quietly Ages Everything
Inflammaging is the chronic, low-grade inflammatory baseline that rises with age and underlies cardiovascular disease, type 2 diabetes, neurodegeneration, and sarcopenia. Fabio Lanzieri — 40 years in pharma — explains the Franceschi and Furman research and what you can actually do about it.
May 26, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Perimenopause Inflammation Symptoms: Why You Hurt, Fog, and Fatigue All at Once
Why new joint pain, brain fog, gut changes, and fatigue in perimenopause share one root: rising inflammatory load as estrogen declines. The estradiol-CRP-IL-6 connection, mapped to symptoms, with honest guidance and real citations.
May 25, 2026·Maria Lanzieri
Pain & Inflammation Signals
The Inflammatory Cascade Explained: A Step-by-Step Guide to How Chronic Inflammation Actually Works
What the inflammatory cascade is, how it works step by step, and why chronic activation drives most modern disease. Clear, researcher-grade explanation.
May 10, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Best Supplements for Menopause Joint Pain: What the Research Actually Supports
8 supplements for menopause joint pain, ranked by real trial evidence — Boswellia, curcumin, omega-3, collagen. Doses, evidence grades, and honest gaps.
May 2, 2026·Fabio Lanzieri
Pain & Inflammation Signals
The Inflammatory Cascade Explained: A Step-by-Step Guide to How Chronic Inflammation Actually Works
Chronic inflammation isn't one thing — it's a cascade of seven steps your body keeps repeating. Here's the step-by-step, with what actually breaks it.
April 29, 2026·Fabio Lanzieri
Pain & Inflammation Signals
What Is Neuroinflammation? (And Why Your Brain Fog Might Not Be "Just Stress")
Brain fog isn't always stress. Sometimes it's neuroinflammation — and the fix isn't more sleep. What it actually is, how to spot it, and what helps.
April 16, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Natural Anti-Inflammatory for Back Pain: Why Most Treatments Miss the Root Cause
If you have been told your back pain is structural — a degenerating disc, a compressed nerve, or just "wear and tear" — that explanation is likely incomplete.
April 15, 2026·Maria Lanzieri
Pain & Inflammation Signals
Anti-Inflammatory Supplements for Joint Pain: What the Evidence Actually Says
If you've tried turmeric supplements and felt underwhelmed, you're not alone — and you're not imagining it.
April 8, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Signs of Chronic Inflammation: Is Your Body Sending You a Signal?
Tired, achy, foggy, or inflamed? Learn the most common signs of chronic inflammation and what multi-pathway support can do.
April 8, 2026·Fabio Lanzieri
Pain & Inflammation Signals
How to Reduce Inflammation Naturally: The Complete Guide
Discover science-backed ways to reduce inflammation naturally — from diet and lifestyle changes to targeted botanicals. Plus, what actually works at the root level.
April 8, 2026·Fabio Lanzieri
Pain & Inflammation Signals
The Science Behind Your Gut - Why 38 Trillion Bacteria Control More Than You Think
38 trillion microbes train your immune system, build neurotransmitters, and talk to your brain. The gut science nobody mentioned — and what actually helps.
April 8, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Inflammation and Brain Fog: The Biological Connection Most People Miss
Curcumin and ibuprofen both reduce inflammation through different pathways. One carries GI risk; one takes weeks. Here's what the clinical data shows.
April 7, 2026·Fabio Lanzieri
Pain & Inflammation Signals
The best anti-inflammatory supplement — what to look for, after 40 years in pharma
Omega-3, curcumin with piperine, boswellia, vitamin D have the strongest human evidence. A pharma scientist ranks the best anti-inflammatory supplements.
April 7, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Gut Inflammation Supplements: How Your Gut Barrier Drives Whole-Body Inflammation
The best gut inflammation supplements target your gut barrier — not just symptoms. Learn how L-Glutamine, Curcumin, and Boswellia support intestinal integrity.
April 7, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Natural Alternative to Ibuprofen
Curcumin matched ibuprofen on pain in a head-to-head trial — with fewer GI events. The research-backed natural alternatives to ibuprofen, and their limits.
April 7, 2026·Fabio Lanzieri
Pain & Inflammation Signals
The Inflammation Cascade: What's Actually Happening When You Hurt
Chronic pain isn't tissue damage — it's an inflammation cascade your body keeps re-running. What's actually happening, and where to interrupt the loop.
March 14, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Anti-Inflammatory Eating: A 7-Day Meal Plan That Actually Works
A 7-day anti-inflammatory meal plan built on peer-reviewed research — not food trends. What to eat, what to cut, and how to make it stick.
March 12, 2026·Fabio Lanzieri
Pain & Inflammation Signals
Pain Signals and the Quieting Response—How GABA Modulates What You Feel
Chronic pain often persists with no tissue damage left to explain it. The reason lives in your nervous system — and GABA is how the brain quiets it.
September 24, 2025·Fabio Lanzieri

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