Inflammation isn’t a feeling. It’s measurable.
The body writes inflammation into the blood — proteins and enzymes that rise when it flares and fall when it calms. Here are the markers research has actually moved, ingredient by ingredient, with the study behind every number.
- inflammatory markers moved
- 7
- standardized actives
- 4
- peer-reviewed studies
- 5
inflammatory markers moved
standardized actives
peer-reviewed studies
What these markers mean
A short glossary, in plain language.
These are the substances a blood test measures to gauge inflammation. Knowing what each one is makes the chart below readable at a glance.
- CRPC-reactive protein
The blood test doctors order most often to gauge inflammation in the body.
A raised CRP is a general signal that systemic inflammation is running high.
- hsCRPHigh-sensitivity CRP
A more precise CRP measurement, sensitive enough to pick up low-grade, chronic inflammation.
Used to detect the slow-burning inflammation that a standard CRP test can miss.
- TNF-αTumour necrosis factor alpha
A master signalling protein (cytokine) that helps switch the inflammatory response on.
A central driver of chronic inflammation — and the target of several prescription drugs.
- IL-6Interleukin-6
A pro-inflammatory cytokine that, among other things, tells the liver to make more CRP.
Rises with chronic inflammation and with age — a key inflammaging marker.
- ESRErythrocyte sedimentation rate
A classic blood test that rises when inflammation is active in the body.
Long used to track active rheumatoid and other inflammatory disease.
- MMP-3Matrix metalloproteinase-3
An enzyme that breaks down cartilage and connective tissue.
Elevated in inflamed, deteriorating joints — a marker of cartilage breakdown.
- MCP-1Monocyte chemoattractant protein-1
A chemokine that recruits immune cells into inflamed tissue.
Higher levels mean more immune traffic to sites of chronic inflammation.
The markers that move
What the research moved, marker by marker.
Each marker lists the standardized actives whose trials lowered it. The bars are scaled to their own measure — read them within a marker, not across.
CRP
C-reactive proteinA raised CRP is a general signal that systemic inflammation is running high.
- ResveratrolMeta-analysis−0.55 SMD-1.2fewer ←0.4
Pooled across 24 randomised trials, resveratrol lowered C-reactive protein — a standardised mean reduction of 0.55.
24 RCTs · Food & Function, 2018
Read the study
hsCRP
High-sensitivity CRPUsed to detect the slow-burning inflammation that a standard CRP test can miss.
- ReducedReduced · 180-day RCT
A 180-day MRI trial in knee osteoarthritis recorded lower hsCRP alongside increased cartilage volume versus placebo.
80 participants · Journal of the American Nutrition Association, 2025
Read the study
TNF-α
Tumour necrosis factor alphaA central driver of chronic inflammation — and the target of several prescription drugs.
- ResveratrolMeta-analysis−0.68 SMD-1.2fewer ←0.4
The same resveratrol meta-analysis pooled a reduction in TNF-α — a standardised mean reduction of 0.68.
24 RCTs · Food & Function, 2018
Read the study - ReducedReduced · 30-day RCT vs placebo
Over 30 days in knee osteoarthritis, boswellia lowered TNF-α alongside MMP-3 and hsCRP.
70 participants · Journal of the American Nutrition Association, 2023
Read the study
IL-6
Interleukin-6Rises with chronic inflammation and with age — a key inflammaging marker.
- L-ArginineRCTReducedReduced · p < 0.01, 6-month RCT
Six months of L-arginine lowered IL-6 (and MCP-1) while improving insulin sensitivity in a cardiometabolic population.
64 participants · Metabolism, 2009
Read the study
ESR
Erythrocyte sedimentation rateLong used to track active rheumatoid and other inflammatory disease.
- CurcuminMeta-analysis−29.47 mm/hr-40fewer ←5
In rheumatoid arthritis, curcumin pooled a 29.47 mm/hr reduction in ESR alongside lower disease-activity scores.
6 studies · 539 participants · Frontiers in Immunology, 2023
Read the study
MMP-3
Matrix metalloproteinase-3Elevated in inflamed, deteriorating joints — a marker of cartilage breakdown.
- ReducedReduced · 30-day RCT vs placebo
The 30-day boswellia trial recorded lower MMP-3 — an enzyme tied to cartilage breakdown — versus placebo.
70 participants · Journal of the American Nutrition Association, 2023
Read the study
MCP-1
Monocyte chemoattractant protein-1Higher levels mean more immune traffic to sites of chronic inflammation.
- L-ArginineRCTReducedReduced · p < 0.01, 6-month RCT
The same L-arginine trial lowered MCP-1, the chemokine that recruits immune cells into inflamed tissue.
64 participants · Metabolism, 2009
Read the study
Each bar is scaled within its own measure — bars are not comparable across markers. Every figure is the result of research on the individual ingredient, not a claim about ProleevaMax.
Markers, explained
Common questions.
References
The studies behind the markers.
Every figure above traces to one of these peer-reviewed studies. Each links to the source.
- 1.Resveratrol supplementation and plasma inflammatory biomarkers: a systematic review and meta-analysis of randomized controlled trials. Food & Function. 2018. https://doi.org/10.1039/c8fo01997e
- 2.Efficacy of Aflapin (Boswellia serrata extract) on knee cartilage and inflammatory markers in osteoarthritis: a 180-day MRI randomized controlled trial. Journal of the American Nutrition Association. 2025. https://doi.org/10.1080/27697061.2024.2440051
- 3.A 30-day randomized controlled trial of Aflapin (Boswellia serrata) in knee osteoarthritis. Journal of the American Nutrition Association. 2023. https://doi.org/10.1080/27697061.2022.2030836
- 4.Curcumin in rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Immunology. 2023. https://doi.org/10.3389/fimmu.2023.1121655
- 5.Long-term oral L-arginine administration improves inflammatory markers and insulin sensitivity in cardiometabolic patients. Metabolism. 2009. https://doi.org/10.1016/j.metabol.2009.05.013
The studies cited here measured the effect of individual ingredients on specific inflammatory markers in specific populations. They are research on the ingredients, not on ProleevaMax, and do not constitute a claim that ProleevaMax lowers any marker or treats any condition.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.