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ProleevaMax pairs thirteen standardized actives across six pathways of the inflammatory response. Here is the published science on each one — the effect sizes, the sample sizes, and the journals, with a link to every study.
peer-reviewed studies
inflammatory pathways
standardized actives
−8.33 pts
Pain (VAS, 0–100) · p < 0.00001
Pooled across 7 trials, boswellia lowered pain on the visual-analog scale and improved WOMAC pain (−14.22) and stiffness.
7 RCTs · 545 participants · ≥ 4 weeks
BMC Complementary Medicine and Therapies, 2020
Ingredient
Boswellia serrata
Cartilage ↑
Knee cartilage (MRI) · p < 0.001
A 180-day MRI trial measured increased cartilage volume, thickness and joint-space width versus placebo, alongside lower hsCRP, MMP-3 and CTX-II.
80 participants · 180 days
Journal of the American Nutrition Association, 2025
Ingredient
Boswellia (Aflapin)
−44.4%
WOMAC pain · significant vs placebo
Over 30 days, WOMAC pain fell 44.4% and VAS pain 45%, with reductions in MMP-3, TNF-α and hsCRP.
70 participants · 30 days
Journal of the American Nutrition Association, 2023
Ingredient
Boswellia (Aflapin)
−1.20 DAS28
Disease activity (DAS28) · p = 0.0003
Curcumin lowered rheumatoid disease-activity scores and ESR (−29.47), with fewer swollen and tender joints.
6 studies · 539 participants · pooled
Frontiers in Immunology, 2023
Ingredient
Curcumin
Improved
Arthritis pain & inflammation · across 5 arthritis types
The largest pooled curcumin analysis to date — across nearly 2,400 participants and five arthritis types — found consistent improvement in pain and inflammatory markers.
29 RCTs · 2,396 participants · 4–36 weeks
Frontiers in Immunology, 2022
Ingredient
Curcumin
−0.55 SMD
CRP (SMD) · p < 0.001
Pooled across 24 trials, resveratrol lowered C-reactive protein (CRP) and TNF-α (SMD −0.68) — two core inflammatory markers.
24 RCTs · pooled
Food & Function, 2018
Ingredient
Resveratrol
79.6% vs 5.8%
Responder rate · p < 0.0001
Glutamine normalized intestinal permeability: 79.6% of participants responded versus 5.8% on placebo, with symptom scores nearly halving.
106 participants · 8 weeks
Gut, 2019
Ingredient
L-Glutamine
−1.5 units
Neuropathy score (CMTNS) · p = 0.03
High-dose L-serine slowed neuropathy progression over a year and shifted the underlying sphingolipid profile.
18 participants · 1 year
Neurology, 2019
Ingredient
L-Serine
Markers ↓
IL-6 & MCP-1 · p < 0.01
Six months of L-arginine lowered IL-6 and MCP-1 and improved insulin sensitivity and adiponectin.
64 participants · 6 months
Metabolism, 2009
Ingredient
L-Arginine
+2,000%
Curcumin bioavailability · landmark PK study
Co-administering piperine raised curcumin bioavailability by up to 2,000% in humans — the reason the two are paired.
Foundational pharmacokinetic citation; supports the delivery rationale, not a clinical outcome.
human crossover · pharmacokinetic
Planta Medica, 1998
Ingredient
Black Pepper (Piperine)
Each bar shows the study’s reported effect, scaled within its own measure — bars are not directly comparable across rows. Every figure is the result of research on the ingredient, not a claim about ProleevaMax.
The studies cited here are research on individual ingredients, not on ProleevaMax. They are presented to explain the science behind the formula and do not constitute a claim that ProleevaMax produces these outcomes.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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