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Inflammation is the body’s repair crew — fast, protective, and built to stand down once the job is done. When it doesn’t, the same machinery that heals starts to harm. Here is how the cascade works, and what happens when it never resolves.
stages from alarm to resolution
pathways the inflammatory response runs through
of global deaths tied to inflammatory disease (Furman 2019)
The two faces
The word “inflammation” covers two things that behave nothing alike. Telling them apart is the whole point.
Acute
Minutes to daysA fast, local, protective response to injury or infection. It ramps up, does its job, and then actively switches itself off. This is healing — the redness and swelling around a cut, the fever that clears an infection.
Chronic
Months to yearsA low-grade, body-wide response that never fully resolves. With no clear threat to fight and a faulty off-switch, it smoulders quietly — and over time the same machinery that heals begins to damage healthy tissue.
The cascade
The inflammatory response runs as a sequence — five stages, from spotting a threat to switching the response back off. Each stage works a little differently, and each is a point where the right ingredient can step in.
The alarm
Your immune cells are covered in tiny sensors that constantly scan for trouble — bits of bacteria, or pieces of your own cells that have been damaged. The moment a sensor spots one, it sounds the alarm and the response begins.456
The master switch
The alarm flips a master switch inside the cell called NF-κB. Think of it like a light switch for inflammation: once it’s on, it turns on the genes that run the whole response.123
The messengers
The cell sends out chemical messengers — proteins called cytokines — that call in backup and turn the response up. It also builds other signals using the COX and 5-LOX enzymes, the very same enzymes that common anti-inflammatory medicines block.7891011
The signs you feel
Nearby blood vessels widen and get leaky, so immune cells can flood into the tissue. This is the part you can actually see and feel: the redness, heat, swelling and pain of inflammation.10
The off-switch
When everything works, the body makes special “stop” signals that switch the response off and clean up the mess. But if that off-switch fails, the response keeps running quietly in the background — and that is chronic inflammation.121314
Resolution
The “stop” signals do their job: the response shuts off, the cleanup finishes, and the tissue goes back to normal. The cascade completes.
Chronic persistence
The off-switch never flips. The response keeps smouldering at a low level, month after month, slowly wearing down otherwise healthy tissue.
When it never switches off
Even without infection, low-grade inflammation creeps upward with age. In 2000 the immunologist Claudio Franceschi named this slow burn “inflammaging.” Two decades of research have since tied it to the major diseases of later life.
Early life
Inflammation flares in response to a real threat, then resolves fully and returns to baseline.
Midlife
The resting level of inflammatory signalling begins a slow, steady climb — the inflammaging curve.15
Later life
Chronic, low-grade inflammation becomes the new baseline — now linked to cardiovascular disease, type 2 diabetes, neurodegeneration and autoimmune conditions.16
50%+
of deaths worldwide are attributable to inflammation-related diseases, making chronic inflammation one of the most significant threats to human health.
Where ProleevaMax fits
You don’t want to stop acute inflammation — it heals you. The goal is helping the body resolve it, and not letting the chronic, low-grade version smoulder. Because the response runs through several connected pathways at once, ProleevaMax was built around six of them — not a single ingredient acting at a single point.
Inflammation, explained
References
Every mechanism described above traces to peer-reviewed primary literature. Numbers in the text link to the source.
This page explains the biology of inflammation and cites research on its mechanisms. It is educational and does not describe outcomes of ProleevaMax. Mechanism statements are not claims that any product produces a specific result.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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