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The research library

Every peer-reviewed study cited across LanFam Health — 70 references behind our ingredient deep-dives, letters, and clinical claims, in one place.

  1. 1.National Center for Complementary and Integrative Health (NCCIH). Asian Ginseng: What You Need To Know. U.S. Department of Health and Human Services. [Premise 8 NIH substitute]. https://www.nccih.nih.gov/health/asian-ginseng
  2. 2.Cao Y, Zhang C, Chen L, et al. L-arginine inhibits arthritis and associated bone loss. Ann Rheum Dis. 2024. https://doi.org/10.1136/ard-2022-223626
  3. 3.Yu W, Sun S, Zhao Y, et al. SIRT1: a promising therapeutic target for chronic inflammatory diseases. Front Immunol. 2024. https://doi.org/10.3389/fimmu.2024.1326460
  4. 4.Mohsenzadeh MS, et al. Effect of frankincense supplementation on knee osteoarthritis: a randomized controlled trial. BMC Res Notes. 2023. https://doi.org/10.1186/s13104-023-06291-5
  5. 5.Perez-Pinero S, et al. Boswellia serrata extract supplementation and knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Nutrients. 2023. https://doi.org/10.3390/nu15173848
  6. 6.Zheng Y, Zhang X, Wu X, et al. The Anti-inflammatory Activity of GABA and Its Active Mechanisms in Lipopolysaccharide-Stimulated Macrophages. Front Nutr. 2023. https://doi.org/10.3389/fnut.2023.1093036
  7. 7.Tian J, Bhupinder S. GABA and the GABAergic System: The Principal Mediator of Neuroinflammation. Biomedicines. 2023. https://doi.org/10.3390/biomedicines11020254
  8. 8.Phone Myint K, Sun Y. Neurological Implications of L-Serine and Its Metabolites. Biomedicines. 2023. https://doi.org/10.3390/biomedicines11082117
  9. 9.Ghorbani P, Santhakumar P, Hu Q, et al. Short-chain fatty acids affect cystathionine-β-synthase and alter epigenetic regulation of choline metabolism. PLoS Pathog. 2023. https://doi.org/10.1371/journal.ppat.1011658
  10. 10.Judd JM, Jasbi P, Winslow W, et al. Inflammation and the pathological progression of Alzheimer's disease is associated with low circulating choline levels. Acta Neuropathol. 2023. https://doi.org/10.1007/s00401-023-02616-7
  11. 11.Tripathi AK, Kohli S. Pharmacological aspects of piperine: a comprehensive review. Beni Suef Univ J Basic Appl Sci. 2022. https://doi.org/10.1186/s43088-022-00196-1
  12. 12.Sokary S, Al-Asmakh M, Zakaria Z, Bawadi H. The therapeutic potential of matcha tea: A critical review on human and animal studies. Curr Res Food Sci. 2022. https://doi.org/10.1016/j.crfs.2022.11.015
  13. 13.Oketch-Rabah HA, Madden EF, Roe AL, Betz JM. United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA). Nutrients. 2021. https://doi.org/10.3390/nu13082742
  14. 14.Wu G, Meininger CJ, McNeal CJ, Bazer FW, Rhoads JM. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Adv Exp Med Biol. 2021. https://doi.org/10.1007/978-3-030-74180-8_10
  15. 15.Foshati S, Ghavami A, Moarabi F, Heidari B, Askari G. The effect of resveratrol supplementation on inflammatory and oxidative stress markers in adults: a systematic review and meta-analysis of randomized controlled trials. Int J Clin Pract. 2021. https://doi.org/10.1111/ijcp.14774
  16. 16.Ye L, Sun Y, Jiang Z, Wang G. L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury. Front Mol Neurosci. 2021. https://doi.org/10.3389/fnmol.2021.726665
  17. 17.Stach K, Stach W, Augoff K. Vitamin B6 in Health and Disease. Nutrients. 2021. https://doi.org/10.3390/nu13093229
  18. 18.Ratan ZA, Youn SH, Kwak YS, et al. Adaptogenic effects of Panax ginseng on modulation of immune functions. J Ginseng Res. 2021. https://doi.org/10.1016/j.jgr.2020.09.004
  19. 19.Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22010181
  20. 20.Yu G, et al. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2020. https://doi.org/10.1186/s12906-020-02985-6
  21. 21.Kochman J, Jakubczyk K, Antoniewicz J, Mruk H, Janda K. Health Benefits and Chemical Composition of Matcha Green Tea: A Review. Molecules. 2020. https://doi.org/10.3390/molecules26010085
  22. 22.Mitoma H, Manto M, Hampe CS. L-Serine Supplementation in Neurological Conditions: Safety Profile and Dosing from Clinical Research. Brain Sci. 2020.
  23. 23.Sasahara I, Yamashita Y, Ohara T, et al. Combined Dietary Supplementation with L-Serine and Fish Oil Alleviates Chronic Pain-Related Symptoms in Subjects with Chronic Pain. J Nutr. 2020. https://doi.org/10.1093/jn/nxaa156
  24. 24.Kusuda R, Cadetti F, Ravanelli MI, et al. Choline dihydrogen citrate reduces inflammatory pain and opioid-sparing effects through the NO/cGMP pathway. Brain Res. 2020. https://doi.org/10.1016/j.brainres.2019.146567
  25. 25.Du J, Zhu M, Bao H, et al. The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling. J Cell Mol Med. 2020.
  26. 26.Stojanović-Radić Z, Pejčić M, Dimitrijević M, et al. Piperine — A major principle of black pepper: A review of its bioactivity and studies. Appl Sci. 2019. https://doi.org/10.3390/app9204270
  27. 27.Ngo DH, Vo TS. An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid. Molecules. 2019. https://doi.org/10.3390/molecules24152678
  28. 28.Wilson RE, Khimani A, Mathur R, et al. Glutamine supplementation reduces opioid use in patients with sickle cell disease and chronic pain. Blood. 2019. https://doi.org/10.1182/blood-2019-126179
  29. 29.Coqueiro AY, Rogero MM, Tirapegui J. Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition. Nutrients. 2019. https://doi.org/10.3390/nu11040863
  30. 30.Qiu Y, Huang Y, Chen M, Yang Y, Li X, Zhang W. Mitochondrial DNA in NLRP3 inflammasome activation. Int J Mol Sci. 2019. https://doi.org/10.3390/ijms20071800
  31. 31.Moretti R, Peinkhofer C. B Vitamins and Fatty Acids: What Do They Share with Small Vessel Disease-Related Dementia?. Int J Mol Sci. 2019. https://doi.org/10.3390/ijms20225797
  32. 32.Yang S, Chang MC. Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Comorbidities. Arthritis Res Ther. 2019. https://doi.org/10.1186/s13075-015-0884-y
  33. 33.EFSA Panel on Food Additives and Nutrient Sources (ANS). Scientific opinion on the safety of green tea catechins. EFSA J. 2018. https://doi.org/10.2903/j.efsa.2018.5239
  34. 34.Unno K, Tanida N, Ishii N, et al. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress. Nutrients. 2018. https://doi.org/10.3390/nu10101468
  35. 35.Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P. Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients. 2018. https://doi.org/10.3390/nu10111564
  36. 36.Khojah HM, Ahmed S, Abdel-Rahman MS, Elhakeim EH. Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study. Medicine (Baltimore). 2018. https://doi.org/10.1097/MD.0000000000011432
  37. 37.Bird RP. The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis. Adv Food Nutr Res. 2018. https://doi.org/10.1016/bs.afnr.2017.11.004
  38. 38.Zheng M, Gu X, Gu Y, et al. Ginsenoside Rg1 inhibits the inflammatory response in LPS-stimulated RAW264.7 macrophages by modulating the NF-κB pathway and suppressing mitochondrial dysfunction. J Agric Food Chem. 2018. https://doi.org/10.1021/acs.jafc.8b02416
  39. 39.Kim MH, Kim H. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Int J Mol Sci. 2017. https://doi.org/10.3390/ijms18051051
  40. 40.Zhou X, He L, Wu C, et al. Serine Alleviates Oxidative Stress via Supporting Glutathione Synthesis and Methionine Cycle in the Liver of Pigs. Mol Nutr Food Res. 2017.
  41. 41.Kim JH, Yi YS, Kim MY, Cho JY. Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. J Ginseng Res. 2017. https://doi.org/10.1016/j.jgr.2016.08.004
  42. 42.Kious BM, Sabic H, Sung YH, Kondo DG, Renshaw P. An Open-Label Pilot Study of Combined Augmentation with Creatine Monohydrate and 5-Hydroxytryptophan for SSRI- or SNRI-Resistant Depression. J Clin Psychopharmacol. 2017. https://doi.org/10.1097/JCP.0000000000000754
  43. 43.Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016. https://doi.org/10.1089/jmf.2016.3705
  44. 44.Ammon HPT. Boswellic acids and their role in chronic inflammatory diseases. Adv Exp Med Biol. 2016. https://doi.org/10.1007/978-3-319-41334-1_13
  45. 45.Hernandez-Rabaza V, Cabrera-Pastor A, Taoro-Gonzalez L, et al. Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by a PPARγ-dependent mechanism. J Neuroinflammation. 2016. https://doi.org/10.1186/s12974-016-0549-z
  46. 46.Wu G, Bazer FW, Burghardt RC, et al. Proline and hydroxyproline metabolism: implications for animal and human nutrition. Mediators Inflamm. 2016. https://doi.org/10.1155/2016/9618795
  47. 47.Ghavidel-Parsa B, et al. The Iceberg Nature of Fibromyalgia Burden: the Clinical and Economic Aspects. BMC Musculoskelet Disord. 2015.
  48. 48.Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of. Curcuma domestica. 2014. https://doi.org/10.2147/CIA.S58535
  49. 49.Gupta SC, Patchva S, Aggarwal BB. Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. AAPS J. 2013. https://doi.org/10.1208/s12248-012-9432-8
  50. 50.Morris CR, Kuypers FA, Lavrisha L, et al. A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes. Haematologica. 2013. https://doi.org/10.3324/haematol.2013.086637
  51. 51.Lee NH, Yoo SR, Kim HG, Cho JH, Son CG. Safety and tolerability of Panax ginseng root extract: a randomized, placebo-controlled, clinical trial in healthy Korean volunteers. J Altern Complement Med. 2012. https://doi.org/10.1089/acm.2011.0591
  52. 52.Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian J Pharm Sci. 2011. https://doi.org/10.4103/0250-474X.93507
  53. 53.Belcaro G, Cesarone MR, Dugall M, et al. Efficacy and safety of Meriva, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010.
  54. 54.Ammon HPT. Modulation of the immune system by Boswellia serrata extracts and boswellic acids. Phytomedicine. 2010.
  55. 55.Csaki C, Mobasheri A, Shakibaei M. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis. Arthritis Res Ther. 2009. https://doi.org/10.1186/ar2850
  56. 56.Binion DG, Otterson MF, Rafiee P. Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. Gut. 2008. https://doi.org/10.1136/gut.2008.152496
  57. 57.Hnia K, Gayraud J, Hugon G, et al. L-arginine decreases inflammation and modulates the nuclear factor-κB/matrix metalloprotease cascade in mdx muscle fibers. Am J Pathol. 2008. https://doi.org/10.2353/ajpath.2008.071009
  58. 58.Ammon HPT. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006. https://doi.org/10.1055/s-2006-947227
  59. 59.Bonkovsky HL. Hepatotoxicity associated with supplements containing Chinese green tea (. Camellia sinensis. 2006.
  60. 60.Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006. https://doi.org/10.1038/nrd2060
  61. 61.Khajuria A, Thusu N, Zutshi U. Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics. Phytomedicine. 2002. https://doi.org/10.1078/0944-7113-00114
  62. 62.Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther. 2002. https://doi.org/10.1124/jpet.102.034728
  63. 63.Shaw K, Turner J, Del Mar C. Tryptophan and 5-Hydroxytryptophan for Depression. Cochrane Database Syst Rev. 2002. https://doi.org/10.1002/14651858.CD003198
  64. 64.Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivasan PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998. https://doi.org/10.1055/s-2006-957450
  65. 65.Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academies Press; 1998. 1998. https://www.ncbi.nlm.nih.gov/books/NBK114310/
  66. 66.Sarzi Puttini P, Caruso I. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. J Int Med Res. 1992. https://doi.org/10.1177/030006059202000210
  67. 67.Caruso I, Sarzi Puttini P, Cazzola M, Azzolini V. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res. 1990. https://doi.org/10.1177/030006059001800304
  68. 68.Titus F, Dávalos A, Alom J, Codina A. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Eur Neurol. 1986. https://doi.org/10.1159/000116030
  69. 69.Atal CK, Dubey RK, Singh J. Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. J Pharmacol Exp Ther. 1985.
  70. 70.Schaumburg H, Kaplan J, Windebank A, et al. Sensory Neuropathy from Pyridoxine Abuse. N Engl J Med. 1983.

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